Effect of Ethanoic Extract of Treculia Africana Seeds on Total Cholesterol, Total Protein, and Nitric Oxide

Gbaranor K. B; Tamuno-Opubo A; Ekene W. E; Chris-Biriwo H; Nelson I. E; Dimkpa B. M.; Modupe O.; Dimkpa C.; Tobin B.; Amuduaghan A. E.

doi:10.5281/zenodo.11099409

Gbaranor K. B Department of Human Physiology, College of Medical Sciences, Rivers State University, Port Harcourt, Nigeria
Tamuno-Opubo A Department of Human Physiology, College of Medical Sciences, Rivers State University, Port Harcourt, Nigeria
Ekene W. E Department of Pharmacology and Therapeutics, College of Medical Sciences, Rivers State University, Port Harcourt, Nigeria
Chris-Biriwo H Department of Human Physiology, College of Medical Sciences, Rivers State University, Port Harcourt, Nigeria
Nelson I. E Department of Human Physiology, College of Medical Sciences, Rivers State University, Port Harcourt, Nigeria
Dimkpa B. M. Department of Community Medicine, University of Port Harcourt Teaching Hospital, Rivers State, South-South, Nigeria
Modupe O. Department of Community Medicine, University of Port Harcourt Teaching Hospital, Rivers State, South-South, Nigeria
Dimkpa C. Department of Paediatrics and Child Health, College of Medical Sciences, Rivers State University, Rivers State, South-South, Nigeria
Tobin B. Department of Community Medicine, University of Port Harcourt Teaching Hospital, Rivers State, South-South, Nigeria
Amuduaghan A. E. Department of Family Medicine, University of Port Harcourt Teaching Hospital, Rivers State, South-South, Nigeria

DOI: https://doi.org/10.5281/zenodo.11099409

Keywords: Effect, Ethanoic, Treculia africana Seeds, Total Cholesterol, Total Protein, Nitric Oxide.

Abstract

Treculia africana is well known and eaten by the people of South-South and South-East region of Nigeria. T. africana can be eaten alone or process and combine it with other fruits. It is nutritious and provide natural bioactive substance to the body. This study was aim to evaluate the Effect of Ethanoic Extract of Treculia africana Seeds on Total Cholesterol, Total Protein, and Nitric Oxide. It was an experimental research. 20 male rats were randomly selected into four groups (control, low dose, moderate dose and high dose groups) with five animals per group. Group A served as control and received only water and pellet feed, Group B (low dose) received 250mg/kg, group C (moderate dose) received 300mg/kgand group D (high dose) received 350mg/kg of aqueous extract of Treculia africana seed respectively. The extract was administered orally to the rats once a day for a period of 10days. On the 11^th day, the animals were anaesthetized with chloroform soaked in cotton wool and blood tissues were collected. The results revealed that,there is significantly increase in the serum levels of total protein in all the treated groups when compared with control (Total protein control 51.40±0.51, low dose 61.60±0.51* medium dose 71.60±0.51*, and 71.80±1.07*). Total cholesterol significantly decreased when both medium and high dose were administered when compared with control (Total cholesterol control 2.34±0.05, medium dose 1.90±0.07*, high dose 1.96±0.19*). Also, nitric oxide significantly increases serum levels in the groups treated with T. africana when compared with control (Nitric oxide control 7.16±0.14, low dose 8.98±0.09*, medium dose 8.50±0.15* and high dose 8.02±0.11*).

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