Evaluating Teratogenic Effects: Examination of the Impact of TCDD on Craniofacial Characteristics and Body Measurements of Isa Brown Chicken Embryos Under Controlled Experimental Conditions

  • Herlina Pratiwi Veterinary Anatomy, Histology and Embryology Laboratory, Faculty of Veterinary Medicine Universitas Brawijaya
  • AEP Haskito Veterinary Public Health Laboratory, Faculty of Veterinary Medicine
  • Ani Setianingrum Veterinary Public Health Laboratory, Faculty of Veterinary Medicine
  • Muhammad Aviv Firdaus Student, Faculty of Veterinary Medicine
  • Adelia Nur Arisanti Student, Faculty of Veterinary Medicine
  • Alfyanda Faerza Student, Faculty of Veterinary Medicine
  • Chanif Mahdi Chemistry Laboratory, Faculty of Mathematics and Natural Science, Universitas Brawijaya, Puncak Dieng Eksklusif, Malang 65145
Keywords: Embryonic development; Body length; Body-wide; Head circle; Head diameter; Seven-day chicken embryo; Malformation; TCDD


2,3,7,8-tetrachlorodibenzo-p-dioxin, sometimes referred to as TCDD is a chemical molecule that is generated via the process of burning. It poses a significant threat to both people and animals due to its toxic effects. The potential adverse effects include dermatological injury, immunosuppression, hepatotoxicity, increased risk of cancer, harm to the developing fetus, reproductive disorders, disruption of development processes, neurobehavioral impairments, and particular endocrine disturbances. Furthermore, this chemical has the capacity to influence the process of embryonic development and increase the rates of embryonic mortality. This study aims to investigate the teratogenic impacts of TCDD injection on the head diameter, head shape, body length, and overall body size of Isa brown embryos. The study consisted of three treatment groups: a control group that did not receive any additional TCDD in corn oil, a placebo group that got 5 µL of corn oil, and a treatment group that received five ng/egg of TCDD dissolved in 5 µL of corn oil. The interventions were administered for a duration of seven days. The statistical analysis revealed that the teratogenic effect of TCDD had a substantial impact on the development of thorax circumference, but it did not affect head diameter, head circumference, overall body size, and body length.


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How to Cite
Pratiwi, H., Haskito, A., Setianingrum, A., Aviv Firdaus, M., Nur Arisanti, A., Faerza, A., & Mahdi, C. (2024). Evaluating Teratogenic Effects: Examination of the Impact of TCDD on Craniofacial Characteristics and Body Measurements of Isa Brown Chicken Embryos Under Controlled Experimental Conditions. GPH-International Journal of Agriculture and Research, 7(01), 01-07. https://doi.org/10.5281/zenodo.10453678