https://gphjournal.org/index.php/ar/issue/feed 2026-08-14T10:47:28+00:00 Dr. EKEKE, JOHN NDUBUEZE drekekejohn@gmail.com Open Journal Systems <p style="font-family: 'Segoe UI', sans-serif; font-size: 16px; color: #333;"><strong>GPH-International Journal of Agriculture and Research (e-ISSN&nbsp;<a href="https://portal.issn.org/resource/ISSN/3050-9602" target="_blank" rel="noopener">3050-9602</a>) </strong>is a peer-reviewed, open-access journal dedicated to advancing agricultural science and practice. The journal publishes original research, comprehensive reviews, and case studies on topics such as crop science, sustainable farming practices, agricultural economics, agri-business management, soil science, and rural development. By fostering interdisciplinary dialogue among researchers, practitioners, and policymakers, it provides a global platform for innovative solutions that promote food security and sustainable development.</p> https://gphjournal.org/index.php/ar/article/view/2553 2026-08-14T10:47:28+00:00 Fittrie Meyllianawaty Pratiwy fittrie.pratiwy@unpad.ac.id Dian Yuni Pratiwi noreplygphjournals@gmail.com

<p>High-fat diets (HFDs) are increasingly used in aquaculture to increase dietary energy density and spare protein for growth, but excessive lipid supply can promote hepatic lipid accumulation, oxidative stress, inflammation, intestinal dysfunction, and impaired metabolic homeostasis. Natural bioactive compounds have therefore attracted attention as functional feed additives capable of improving metabolic resilience. This critical review evaluates evidence from fish studies on curcumin, resveratrol, chlorogenic acid, berberine, quercetin, tea polyphenols, hydroxytyrosol, glycyrrhetinic acid, and related plant-derived compounds used under high-fat or high-lipid feeding conditions. Particular attention is given to mechanisms involving PPAR-mediated fatty-acid oxidation, SREBP/FAS-regulated lipogenesis, AMPK-associated energy sensing and mitochondrial quality control, Nrf2-linked antioxidant defense, and NF-κB-associated inflammatory signaling. Across the available evidence, several natural bioactives reduce hepatic or circulating lipid accumulation and improve antioxidant, inflammatory, histological, or metabolic indicators, although growth responses are less consistent. Responses depend strongly on fish species, dietary lipid level and source, bioactive dose, feeding duration, compound purity, and the physiological endpoint examined. Current evidence therefore supports selected natural bioactives primarily as metabolic modulators rather than universal growth promoters. Future research should emphasize standardized HFD models, dose-response designs, chemical characterization of extracts, correct identification of the experimental unit, mechanistic validation, and testing under commercial farming conditions.</p>

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