Influence of Craterispermum schweinfurthi leaf extract on glucose homeostasis in male Wistar rats

Saronee F; Okari K; Nwikue G; Dimkpa VO; Ante IA

doi:10.5281/zenodo.16811222

Saronee F Department of Physiology Faculty of Basic Medical Sciences PAMO University of Medical Sciences, Nigeria
Okari K Department of Medical Biochemistry Faculty of Basic Medical Sciences College of Medicine Rivers State University, Nigeria
Nwikue G Department of Pharmacology Faculty of Basic Clinical Sciences College of Medicine Bayelsa Medical University Yenagoa, Bayelsa State, Nigeria
Dimkpa VO Department of Animal and Environmental Biology Faculty of Science Rivers State University Port-Harcourt,Nigeria
Ante IA Department of Physiology Faculty of Basic Medical Sciences PAMO University of Medical Sciences, Nigeria

DOI: https://doi.org/10.5281/zenodo.16811222

Keywords: Antihyperglycemic, Craterispermum schweinfurthi, diabetes, alloxan, anti-diabetic

Abstract

The present study aims to determine the potential influence of Craterispermum schweinfurthi leaf extract on glucose homeostasis using male Wistar rats as models. 48male Wistar rats were acclimatized and subsequently randomly divided into 6 groups of 8 rats each. Diabetes was induced in all rat groups except Group 1 using alloxan at a dose of 200mg/kg bw administered intraperitonially. Diabetes was confirmed after 72 hours of alloxan administration if the blood glucose level is ≥ 11.1 mmol/L (200mg/dl) and was daily treated with different concentrations of extract.Compared to group 2 (Untreated Diabetic) rats, administration of graded doses ofthe extract of Craterispermum schweinfurthi amongstGroups 3, 4 and 5 rats demonstrated a dose dependent significant reduction (p<0.05)in blood glucose level and glycosylated hemoglobin concentrationwith the highest dose demonstrating the most impactful outcome. Suggesting a possible hypoglycemic and anti-hyperglycemic effects of the extract. Similar results were observed amongst group 6rats followingadministration of Glibenclamide. Treatment of diabetic rats with hydromethanol leaf extract of Craterispermum schweinfurthi lowered blood glucose level and ameliorated glycosylated hemoglobin concentration in male Wistar rats.

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