Comparative study of safety and efficacy of cryotherapy followed by intralesional corticosteroid injection versus intralesional injection of corticosteroid plus 5- flurouracil in the treatment of keloid

  • Dr. Mohammad Fokhruzzaman Assistant Professor, Department of Skin & VD, Directorate General of Health Services (DGHS), Bangladesh
  • Dr. Mohammad Abu Hena Assistant Professor, Department of Skin & VD, Bangabandhu Sheikh Mujib Medical University (BSMMU),Bangladesh
  • Shahid Afridi Lecturer, Department of Physiotherapy, SAIC College of Medical Science & Technology, Bangladesh https://orcid.org/0000-0002-9558-5640
  • Dr. Syeda Sushmita Zafar Assistant Professor, SAIC College of Medical Science and Technology (SCMST), Mirpur-14, Dhaka- 1216, Bangladesh
  • Rubaya Sultana Department of Development Studies, Islamic University, Kushtia, Bangladesh
  • Jannatul Taslima Meem Clinical Physiotherapist, Department of Physiotherapy, Centre for the Rehabilitation of the Paralysed (CRP), Dhaka-1343
  • Prof. Dr. Lt. Col (Rtd.) Md. Abdul Wahab Professor, Department of Skin & VD, Bangabandhu Sheikh Mujib Medical University (BSMMU),Bangladesh
DOI: https://doi.org/10.5281/zenodo.13208767
Keywords: Cryotherapy, Intralesional corticosteroid injection, Intralesional 5-fluorouracil, Keloid treatment, Scar management

Abstract

Background: Keloid is an overgrowth of dense, fibrous tissue, usually developing after healing of a skin injury and extends beyond the borders of the original wound. The treatment of keloid has been a challenge, and at times, frustrating because of the recurrence.

Objective: To compare the safety and efficacy of cryotherapy followed by intralesional corticosteroid injection versus intralesional injection of corticosteroid plus 5- flurouracil in the treatment of keloid.

Materials and methods: The Department of Dermatology & Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka conducted a cross-sectional comparative study on 70 outpatients with clinically diagnosed keloids. SPSS 23 was used to analyses data. The significance threshold of p < 0.05 was analyzed using the chi-square test and student “t” test. Mean standard deviation was used for continuous scale data and number percentage for categorical data.

Results: TAverage age was found 33.5±9.3 years in group A, 31.7±10.3 in group B. Scar height was 3.47±0.99 mm in group A and 3.59±0.61 mm in group B. At the first follow-up, scar height was significantly larger in group A (2.54±0.87 vs 2.12±0.54 mm) than group B. At 2nd follow-up, scar height was considerably greater in group A (1.85±1.01 vs 1.10±0.43 mm) than group B Group A had 17 (48.6%) efficacy and group B 26 (74.3The end outcome was good to excellent for 16 (45.7%) in group A and 25 (71.4%) in group B. The two groups showed a significant difference (p<0.05). Side effects included 6 (17.1%) skin atrophy in group A but none in B. Telangiectasia was 8(22.9%) in group A and 1(2.9%) in B. Hypopigmentation was 7(20.0%) in group A and absent in B. Ulceration was 47 (11.4%) in group B but not in A. Group A had 14 (40.0%) recurrence and group B 6 (17.1%). The two groups showed a significant difference (p<0.05).

Conclusion: Cryotherapy followed by intralesional corticosteroid with 5-fluorouracil treating keloids is more effective, lasts less, and has less side effects than Cryotherapy alone. Cryotherapy followed by intralesional corticosteroid plus 5-fluorouracil reduces scar height considerably.

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Published
2024-08-04
How to Cite
Fokhruzzaman, D. M., Abu Hena, D. M., Afridi, S., Sushmita Zafar, D. S., Sultana, R., Taslima Meem, J., & Abdul Wahab, P. D. L. C. (Rtd.) M. (2024). Comparative study of safety and efficacy of cryotherapy followed by intralesional corticosteroid injection versus intralesional injection of corticosteroid plus 5- flurouracil in the treatment of keloid. GPH-International Journal of Biological & Medicine Science, 7(07), 09-16. https://doi.org/10.5281/zenodo.13208767
Issue
Vol 7 No 07 (2024): GPH-INTERNATIONAL JOURNAL OF BIOLOGICAL & MEDICINE SCIENCE
Section
Articles
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