ALTERATIONS IN LIPID PROFILE OF NORMAL MALE WISTAR RATS ADMINISTERED AQUEOUS EXTRACTS OF PHOENIX DACTYLIFERA,CYPERUS ESCULENTUS,SOYBEAN AND LIQUID COD-LIVER OIL
Abstract
This research study was designed to determine changes in lipid profile of normal male wistar rats subjected to daily oral administration of 1000mg/kg phoenix dactylifera, 1600mg/kg Cyperus Esculentus, 1000mg/kg soybean aqueous extracts and 0.5ml liquid cod liver oil for five weeks. The lipids profile analyzed in this study includes total serum cholesterol, triglyceride, high density, low density, and very low density lipoproteins using enzymatic point millimoles and precipitant methods measured in mill moles per liter. Other parameters examined are weight measurement in grams and fasting blood sugar level in millimoles per liter respectively. Results: The result from this study shows an increase in serum total cholesterol (4.10mmol/l), triglyceride (1.71mmol/l), HDL (1.78mmol/l) and low density lipoprotein (3.09mmol/l) compared with the control group. There was an increase in LDL among the test groups except in group 4 that received 1000mg/kg extract of soybean having a decrease of 2.08mmol/l compared with control (2.22mmol/l). A non-significant decrease in very low density lipoprotein was also observed among the test groups except in grop2 (0.73mmol/l) compared with the control (0.70mmol/l). More findings from this study revealed a very strong positive correlation between serum total cholesterol versus other lipoproteins and between HDL versus other lipid parameters examined. Further observation from this study indicate a decrease in weight among the test groups at the end of the 5ͭᵗͪ week of the study compared with week one and the control. The FBS level was significantly decreased among the entire test group that received the aqueous extract of Cyperus Esculentus and phoenix dactylifera. Conclusion: The aqueous extract of phoenix dactylifera and Cyperus Esculentus significantly and effectively reduces the weight, fasting blood sugar and triglyceride levels with an inverse increase in the concentration of good cholesterol (HDL) needed for the maintenance of cardiovascular health status among study groups.
Downloads
References
Alfred T (2002)."Fats and Fatty Oils". Ullmann's Encyclopedia of Industrial Chemistry. Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH
Association of official analytical chemist (2016). Official methods of analysis of AOAC international (20thEd).
Beyersmann D, Hartwig A. (2008). Carcinogenic metal compounds: recent insight into molecular and cellular mechanisms. Arch Toxicol.; 82(8):493–512
Bhattacharjee CR, Dey S, Goswami P (2003). Protective role of ascorbic acid against lead toxicity in blood of albino mice as revealed by metal uptake, lipid profiles and ultrastructural features of erythrocytes. Bull Environ Contam Toxicol, 70:1189-1196.
Bronner LL, Kanter DS, Manson JE (1993).Primary prevention of stroke. New England Journal of Medicine 333(23):1392-1400
Isdadiyanto S et al (2020). The lipid profile of rats induced by high fat ration after expose to ethanolic neem (Azadirachta Indica) leaf extract. Journal of Physics: conference series 1524:012126
James AG and Richard JS (2022).Basics of blood sugars. The Ohio State University Comprehensive cancer center Research Institute
Kenneth R and Feingold MD (2024). Introduction to lipids and lipoproteins. National Library of Medicine www.endotext.org
Malik EI and Sabahelkhier MK (2019).Changes in lipid profile and heart tissues of wistar rats induce by using monosodium glutamate as food additive. International Journal of Biochemistry and Physiology 4(1):000147
Marriam Webster.com Dictionary 2023
Onyeali EU, Arthur CO, Comfort CM, Michael OM (2010).Plasma lipid profile of wistar rats fed with palm oil supplemented diets. International Journal of Biological and Chemical Sciences 4(4):1163-1169.
Panelniva S & Ossie S (2019).Prevention and control: Nutrition, Obesity and Metabolism. Encyclopedia of cancer – Third Edition p278-291
Simon H, Christine W, Walter V (2015):Analysis of intact cholesteryl esters of furan fatty acids in cod liver (AOCS) https://doi.org/10.1007/s11745-015-4019-7
Solomon MU,Asara AA, Bruno C,Bonnie KG (2017).Correlation of serum cholesterol, electrolytes and body mass index with cardiovascular status of selected adults in Bayelsa state Nigeria. European Journal of Pharmaceutical and Medical Research 4(7):110-117
Solomon MU,Bonnie KG,Tabowei OC,Ngaikedi FNC (2017). The serum cholesterol and blood pressure of selected adults in Bayelsa state Nigeria. European Journal of Pharmaceutical and Medical Research 4(7): 39- 44
Solomon MU,Kiridi Emily GE,Blessing LD (2023).Lipid profile normalization effect of hunteria umbelata aqueous fruit extract in wistar rats induced with aloxan monohydrate. International Journal of Pharmaceutical and Bio-medical Science 3(5):195-200
UCLADLAMRev (2013). The clinical chemistry of laboratory animals 2nded Philadelphia. Taylor and Francis USA (Modified from Loeb et al.,1999).
Vetter W, Wendlinger C (2013).Furan fatty acids-valuable minor fatty acids in food lipid techinol 25(1):7-10
Author(s) and co-author(s) jointly and severally represent and warrant that the Article is original with the author(s) and does not infringe any copyright or violate any other right of any third parties, and that the Article has not been published elsewhere. Author(s) agree to the terms that the GPH Journal will have the full right to remove the published article on any misconduct found in the published article.
